The singer came back to the city to headline the #OneLoveManchester concert to honor the victims of the tragedy, which left 22 dead and dozens of others injured.
The show featured live performances by Grande, Pharrell Williams, Katy Perry, Justin Bieber, Robbie Williams, the Black Eyed Peas, Miley Cyrus, Coldplay and Oasis' Liam Gallagher.
“I think that the kind of love, the unity that you’re displaying is the medicine that the world really needs right now,” the 23-year-old told the 50,000-person crowd.
She thanked the audience inside Manchester’s Old Trafford Cricket Ground for being “strong and unified.”
The concert came less than 24 hours after terror again struck the U.K., as seven civilians were killed after a van drove over pedestrians on London Bridge, and attackers started randomly stabbing citizens.
Scooter Braun, who manages both Grande and Bieber, praised the crowd for their bravery following both attacks.
“Last night, this nation was challenged, and all of you were challenged, and you had a decision to make if you were going to come out here tonight, and this is so beautiful," he said. "You guys made that decision. You looked fear right in the face and you said, No, we are Manchester, and the world is watching."
“We will not be silenced” Katy Perry told the crowd as she belted out some of her biggest hits during the gig, which raised more than $3 million.
Combined with donations to the British Red Cross from those watching the concert from their TVs and livestreams, contributions have exceeded $13 million.
When Coldplay took the stage, they serenaded Grande with the Oasis classic “Don’t Look Back in Anger,” which has become an anthem of healing following the May 22 attack.
“We all want to say thank you, Ariana, to you for being so strong and wonderful,” Coldplay singer Chris Martin said. “You’ve been singing a lot for us so I think we of Britain want to sing for you. This is called 'Don’t Look Back in Anger' and this is for you.”
Manchester resident and former Oasis frontman Liam Gallagher made a surprise appearance. He performed his latest solo single as well as two songs from his former band, dedicating one, “Live Forever,” to the people of Manchester while teaming up with Martin for the duet.
Gallagher tweeted on Monday morning how honored he was to perform.
What an amazing night last night pure love vibrations nobody comes close to Manchester love forever LG x— Liam Gallagher (@liamgallagher) June 5, 2017
It was rumored that Oasis were going to reunite for the concert, but it never came to fruition as Gallagher's brother Noel did not attend.
Manchester id like to apologise for my brothers absence last night very disappointed stay beautiful stay safe LG x— Liam Gallagher (@liamgallagher) June 5, 2017
Grande, who had the crowd in tears as she sang "Over the Rainbow," is receiving praise for her courage and empathy in staging the concert on social media.
Ariana Grande is such a beautiful human with a beautiful soul ❤️? pic.twitter.com/i9Gy5YPwom— Dean Boroczky (@DeanomusicUK) June 5, 2017
Ariana Grande. Manchester. Somewhere over the rainbow. Such youth. Such hope. Such class.— Derryn Hinch (@HumanHeadline) June 5, 2017
The day before the historic gig, the singer attended a local hospital and met some of her fans who were injured in the attack.
Tickets for the benefit concert went on sale Thursday morning and sold out in less than 20 minutes.
Concert organizers set aside more than 14,000 free tickets for fans who attended the original concert, but more than 25,000 people sent in applications, meaning about 45 percent of the applicants were lying.
Ticket scalpers were attempting to resell the $52 tickets for as much as $500, leading Ticketmaster and eBay to take measures to weed out scalpers.
eBay tweeted a statement that warned, "Please do not attempt to sell # OneLoveManchester tickets on our site. We are actively removing all listings & restricting sellers who try to."
Ticketmaster wrote: "#OneLoveManchester we're working hard to get tickets direct to fans. We are canceling tickets of those who are reselling wherever possible."
Grande will resume her current "Dangerous Woman" tour later this month after putting it on hold following the terrorist attack.