The "Ocean’s 11" actor is currently filming Hulu’s "Catch-22" series on the island.
He was on his way to the set at 8:15 a.m., reportedly driving 60 miles per hour on State Road 125 when a male driver did not "respect the right of way" and cut off Clooney’s scooter, the Italian Carabinieri said in a statement.
Clooney was wearing a helmet, which was broken by the force of the impact on the Mercedes. The actor is said to have been hurled 20 feet in the air.
Clooney was taken to a nearby hospital in the city of Olbia after complaining of a "slight trauma to the pelvis and bruises to one leg and an arm."
"George was treated and released," his rep said. "He is recovering at home and will be fine."
Clooney's wife, Amal, who is also in Sardinia with their 1-year-old twins, rushed to her husband’s side. Upon his discharge from the hospital, they were driven away in a minivan.
Clooney suffered a bruised knee and will make a full recovery in 20 days, according to reports.
Authorities are investigating whether charges will be filed.
This isn't the first time that Clooney has been involved in a scary crash.
Back in 2007, he was driving a rented Harley-Davidson with then-girlfriend Sarah Larson when they were sideswiped on a narrow road in New Jersey. Larson, a former cocktail waitress, broke two toes and hobbled on crutches afterward. Clooney broke a rib.