Another 14 people were injured, including three critically, when the team bus reportedly collided with a semi-truck on Highway 35 in Tisdale, Saskatchewan, at 5 p.m. Friday.
Police said there were 28 people, including the driver, aboard the Humboldt Broncos' bus when the crash took place.
Police have not released any identities of the deceased. Members on the team reportedly ranged in age from 14 to 21.
"I cannot imagine what these parents are going through, and my heart goes out to everyone affected by this terrible tragedy, in the Humboldt community and beyond," Canadian Prime Minister Justin Trudeau tweeted.
The team’s president, who was not on the bus at the time, said it was the hardest day of his life after hearing of the tragedy.
"There have been multiple fatalities — our whole community is in shock, we are grieving and we will continue to grieve throughout this ordeal as we try to work toward supporting each other," Kevin Garinger said.
A photo of three of the team's players holding hands in adjacent hospital beds, one wearing a neck brace, was posted to Twitter after the crash.
“Derek Grayson and Nick bonding and healing in hospital,” the text above the heartbreaking image read.
One father of a player on the team described the scene as a "disaster."
“We had a crane lifting the bus," Myles Shumlanski, father of Broncos player Nick Shumlanski, told the Saskatoon Star Phoenix.
A GoFundMe campaign has been started to raise money for the victims.