Many have taken to social media to share personal stories of how the pop star helped them through their battles with addiction, mental illness and body image issues.
Lovato recorded "Skyscraper" in 2011 after completing treatment for "emotional and physical issues."
"In 7th grade I had my suicide note written & struggled with self-harm & 'Skyscraper' saved me," read one heartfelt tweet.
"Skyscraper brought me out of depression," another said.
TV personality Kelly Osbourne knows what Lovato is going through. She's been open about her battle with drugs and alcohol and says she fights every day to stay sober.
“I can’t imagine what Demi’s going through right now, even though I know what it’s like to have the whole world talk about you in your most vulnerable state,” she said this week on the British talk show, "Loose Women."
"We know each other," she added. "Look, I will never speak on behalf of Demi because that wouldn’t be right. I can only share about what I’ve been through and what I know from myself. And that is, relapse is one of the hardest things we face as an open addict who has gone through the program and turned their life around."